The SYNGAP International Patient Registry will organize a system of information that will use observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for SYNGAP mutations, condition or exposure, and that serves one or more predetermined scientific, clinical, or policy purpose.  In addition to providing clinically relevant data that are meaningful to patients and providers, this registry will have the ability to provide data on SYNGAP mutations not typically studied. The SYNGAP registry can offer adaptable designs and data collection strategies, making them particularly useful when treatments are rapidly changing. The registry will reveal potential bio-markers and crucial data for scientists that will speed up the development of drugs and new treatments for individuals with SYNGAP mutations.  The non-experimental design of this registry can be used to examine the impact of physician practice behaviors on quality of care, prescribing preference, and other important but difficult to quantify covariances.  This data will be accessible to researchers and doctor’s worldwide with the opportunity to coordinate efforts to produce new research and efforts to develop new hypothesis’ to study.